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Cure to TB may be living at the bottom of Lake Michigan

March 24th, 2015 by
Scientists at the University of Illinois at Chicago have unearthed a species of Lake Michigan bacteria that may become a powerful weapon in the fight against tuberculosis. Found in the sediment off the coast of Milwaukee, the microbe’s medicinal power lies in the small compounds it makes to defend itself. 
 


UIC researcher Brian Murphy and colleagues at the College of Pharmacy are still trying to pin down how the molecules attack the M. tuberculosis bacterium, but they know that the compounds display drug-like potency against a range of antimicrobial-resistant strains that rivals existing clinical treatments.
 
This study is part of a larger effort by Murphy and others to determine the disease-fighting potential of aquatic actinomycete bacteria. Current treatments for many diseases are built around the chemical defenses used by land-based bacteria, but a growing number of pathogens are now resistant to standard drugs. Results like these in Lake Michigan suggest that freshwater bacteria may create molecules that dangerous pathogens have yet to evolve defenses against, making the Great Lakes a potentially untapped reservoir of treatments for some of the world’s deadliest diseases.  
 
To understand the potential of the lakes, Murphy has collected more than 600 strains of freshwater actinomycete bacteria with support from an IISG Discovery Grant. The size and diversity of the library will help reveal both whether these bacteria are significantly different than their land-based cousins and if strains found in different lakes produce unique chemical defenses.

 

This analysis is still underway, but Murphy and his team have already discovered that the makeup of actinomycete communities in Lake Huron varies both by location and depth, a diversity that makes the lake a potentially important site in the hunt for new cures. 

UpClose with Steve Mauro

August 6th, 2014 by
Steve Mauro’s research into the impacts of pharmaceutical and personal care products (PPCPs) on bacterial communities may have started as a small side project, but it has become so much more. The Gannon University dean gained national attention in 2011 when he and his research team discovered that small concentrations of fluoxetine are killing E. coli in the nearshore waters of Lake Erie. Today, Mauro continues to investigate exactly where and how fluoxetine and other pharmaceutical chemicals, both individually and combined, are changing the microbes that keep aquatic ecosystems healthy. And it is this work that brought IISG to his office bright and early on a June morning.
 
In this issue of UpClose, Mauro goes beyond his work on PPCPs to talk about the importance public outreach and about new efforts that are making it easier for forecasters and beach managers to predict when E. coli levels may make a trip to the beach more trouble than its worth.
 
Check out this and previous issues of UpClose at unwantedmeds.org

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A recent @seagrant_noaa publication, Aquaculture Regulation in the Great Lakes, serves as a valuable resource for fish farmers & policymakers in the region in navigating the complex legal environment of aquaculture.The report breaks down complex legal framework and provides practical insights to help aquaculture producers understand and navigate state and regional requirements with greater confidence.It was developed by the National Sea Grant Law Center in partnership with @mnseagrant-led Great Lakes Aquaculture Collaborative (GLAC) which formed to support aquaculture in the eight Sea Grant programs that border the Great Lakes and Lake Champlain. Read more and access the report at the link in bio.
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