Scientists at the University of Illinois at Chicago have unearthed a species of Lake Michigan bacteria that may become a powerful weapon in the fight against tuberculosis. Found in the sediment off the coast of Milwaukee, the microbe’s medicinal power lies in the small compounds it makes to defend itself.
UIC researcher Brian Murphy and colleagues at the College of Pharmacy are still trying to pin down how the molecules attack the M. tuberculosis bacterium, but they know that the compounds display drug-like potency against a range of antimicrobial-resistant strains that rivals existing clinical treatments.
This study is part of a larger effort by Murphy and others to determine the disease-fighting potential of aquatic actinomycete bacteria. Current treatments for many diseases are built around the chemical defenses used by land-based bacteria, but a growing number of pathogens are now resistant to standard drugs. Results like these in Lake Michigan suggest that freshwater bacteria may create molecules that dangerous pathogens have yet to evolve defenses against, making the Great Lakes a potentially untapped reservoir of treatments for some of the world’s deadliest diseases.
To understand the potential of the lakes, Murphy has collected more than 600 strains of freshwater actinomycete bacteria with support from an IISG Discovery Grant. The size and diversity of the library will help reveal both whether these bacteria are significantly different than their land-based cousins and if strains found in different lakes produce unique chemical defenses.
This analysis is still underway, but Murphy and his team have already discovered that the makeup of actinomycete communities in Lake Huron varies both by location and depth, a diversity that makes the lake a potentially important site in the hunt for new cures.
Steve Mauro’s research into the impacts of pharmaceutical and personal care products (PPCPs) on bacterial communities may have started as a small side project, but it has become so much more. The Gannon University dean gained national attention in 2011 when he and his research team discovered that small concentrations of fluoxetine are killing E. coli in the nearshore waters of Lake Erie. Today, Mauro continues to investigate exactly where and how fluoxetine and other pharmaceutical chemicals, both individually and combined, are changing the microbes that keep aquatic ecosystems healthy. And it is this work that brought IISG to his office bright and early on a June morning.
In this issue of UpClose, Mauro goes beyond his work on PPCPs to talk about the importance public outreach and about new efforts that are making it easier for forecasters and beach managers to predict when E. coli levels may make a trip to the beach more trouble than its worth.
Check out this and previous issues of UpClose at unwantedmeds.org.
- Illinois-Indiana Sea Grant Announces 2023 Fellows for the John A. Knauss Marine Policy Fellowship Program
- Funding opportunity open for 2024-25 research projects
- National Sea Grant partnerships address water equity in marginalized neighborhoods
- Apply now for the 2024 Knauss Fellowship in Washington, D.C.
- IISG invites applications for faculty and graduate scholars programs
- Aquatic Invasive Species
- Climate Ready Communities
- Director's Blog
- Funded Research
- Great Lakes Cleanup
- Great Lakes Data
- Healthy Waters
- Recreation & Tourism
- Sea Grant Scholars
- Stormwater & Green Infrastructure
- Sustainable Community Planning
- The Helm
- Water Supply